About us

Our mission

·         Identification of cell-type specific molecular pathways responsible for the regulation of thyroid hormone homeostasis in the brain and coupled peripheries

·         To understand the role of these mechanisms in certain physiological and pathological brain processes

·         To develop transgenic, cellular and diagnostic models to measure and manipulate local thyroid hormone signalling

Thyroid hormones (TH) are critically important regulators of cell metabolism and differentation. These hormones exert a fundamental influence on brain development and function, primarily through influencing transcriptional activity. With many millions of people worldwide suffering from some form of TH disorder, which has been linked to a wide range of neurological and other diseases, characterizing TH economy is a major health issue today.

To achieve our mission, our group combines molecular, cell biology, anatomy and transgenic techniques, used in our basic science and translational projects.

Our main projects

·         Molecular basis of T4 monotherapy, the dominant treatment for hypothyroidism

·         Investigation of the molecular regulation of the deiodinase enzyme system responsible for TH metabolism, with special emphasis on the ubiquitination of type 2 deiodinase

·         Study of intracellular transport of TH

·         Investigation of the mechanisms of the nonthyroidal illness syndrome

·         Development and use of tissue-based diagnostic methods to characterize local TH economy in human cases where routine procedures are inadequate

·         Investigation of the impact of environmental pollutants on TH homeostasis