We live in an ever-changing world. Our survival and well-being depend on how we can adapt to it by momentarily readjusting our actions. In order to do so, we have to filter out unimportant inputs and store only relevant information. Then, based on the combination of freshly acquired information and our memories, we select an action plan matching the actual situation. Subcortical modulation, by influencing all stages of cortical information processing, is indispensable for the selection, storage and recall of information and for carrying out the optimal action. Our lab aims to unravel the operational principles of subcortical modulation by studying how the hippocampus, the center of the brain's episodic memory circuitry, is influenced by subcortical modulators. We focus on the connection between the hippocampus and two of its main modulatory inputs, the medial septum and the median raphe. The former is thought to be pivotal for orchestrating the activity of hippocampal coding neuronal assemblies whereas the latter may affect the storage of certain types of information.